Expression patterns and action analysis of genes associated with physiological responses during rat liver regeneration:Innate immune response
Expression patterns and action analysis of genes associated with physiological responses during rat liver regeneration:Innate immune response作者机构：College of Life Science Lanzhou University Lanzhou 730000 Gansu Province China College of Life Science Henan Normal University Xinxiang 45300 Henan Province China Key Laboratory for Cell Differentiation Regulation Xinxiang 453007 Henan Province China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2006年第12卷第48期
页 面：7852-7858页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by the National Natural Science Foundation of China No. 30270673
主 题：Partial hepatectomy Rat genome 230 2.0 array Innate immune response Genes associated with liver regeneration
摘 要：AIM： To study the relationship between innate immune response and liver regeneration （LR） at transcriptional level. METHODS： Genes associated with innate immunity response were obtained by collecting the data from databases and retrieving articles, Gene expression changes in rat regenerating liver were detected by rat genome 230 2.0 array. RESULTS： A total of 85 genes were found to be associated with LR. The initially and totally expressed number of genes at the phases of initiation [0.5-4 h after partial hepatectomy （PH）], transition from GO to G1 （4-6 h after PH）, cell proliferation （6-66 h after PH）, cell differentiation and structure-function reconstruction （66-168 h after PH） was 36, 9, 47, 4 and 36, 26, 78, 50, respectively, illustrating that the associated genes were mainly triggered at the initial phase of LR and worked at different phases. According to their expression similarity, these genes were classified into 5 types： 41 up-regulated, 4 predominantly up-regulated, 26 downregulated, 6 predominantly down-regulated, and 8 approximately up/down-regulated genes, respectively. The expression of these genes was up-regulated 350 times and down-regulated 129 times respectively, demonstrating that the expression of most genes was enhanced while the expression of a small number of genes was decreased during LR. Their time relevance was classified into 14 groups, showing that the cellular physiological and biochemical activities dudng LR were staggered. According to the gene expression patterns,they were classified into 28 types, indicating that the cellular physiological and biochemical activities were diverse and complicated during LR. CONCLUSION： Congenital cellular immunity is enhanced mainly in the forepart, prophase and anaphase of LR while congenital molecular immunity is increased dominantly in the forepart and anaphase of LR. A total of 85 genes associated with LR play an important role in innate immunity.
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