阿尔茨海默病的非血浆铜蓝蛋白血清铜过量与MMSE、CSF β-淀粉样蛋白和h-tau水平相关

作     者：Squitti R. Barbati G. Rossi L. 郭俊 

作者机构：00186 Rome Dr.AFaR Department of Neuroscience AFaR Hospital Fatebenefratelli Italy 

出 版 物：《世界核心医学期刊文摘(神经病学分册)》 (Digest of the World Core Medical Journals.Clinical Neurology)

年 卷 期：2006年第12期

页      面：13-14页

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

主　　题：β-淀粉样蛋白 阿尔茨海默病 MMSE h-tau 血浆铜蓝蛋白 金属蛋白 CSF 血清铜 

摘      要：OBJECTIVE:To assess whether serum copper in Alzheimer disease(AD)correlates with cognitive scores,β-amyloid,and other CSF markers of ***:The authors studied copper,ceruloplasmin,total peroxide,and antioxidants levels(TRAP)in serum;β-amyloid in plasma;and copper,β-amyloid,h-tau,and P-tau in the CSF of 28 patients with AD and 25 healthy controls,in relation to clinical ***:Serum copper(p 0.0001),peroxides(p = 0.002),a copper fraction unexplained by ceruloplasmin(p 0.0001),and CSF h-tau(p = 0.001)were increased in AD,whereas serum TRAP(p = 0.03)and CSF β-amyloid were decreased(p 0.0001).Plasma β-amyloid increased with age in healthy controls(r = 0.6;p = 0.05).CSF markers of AD correlated with serum copper *** copper was partially dependent on the serum copper fraction unexplained by ceruloplasmin(t = 2.2,p = 0.04).CSF β-amyloid seemed to be related to serum copper(r =-0.46;p = 0.002).Mini-Mental Status Examination scores correlated positively with β-amyloid(r = 0.46,p = 0.002)and inversely with copper unexplained by ceruloplasmin(r =-0.45,p = 0.003).CONCLUSIONS:The authors’results confirm the existence of changes in copper component distribution,particularly the copper fraction unexplained by ceruloplasmin and support the hypothesis of a β-amyloid and copper connection in Alzheimer disease.