Design,synthesis and biological activity of some novel benzimidazole derivatives against Coxsackie virus B_3

作     者：Zhong Lv Zhang Zhi Jie Sun Fei Xue Xian Jin Luo Nai Yun Xiu Li Teng Zong Gen Peng 

作者机构：School of Chemistry and Chemical Engineering Shanghai Jiaotong University Shanghai 200240 PR China School of Life Science and Environmental Science Shanghai Normal University Shanghai 200234 PR China cInstitute of Medicinal Biotechnology Chinese Academy of Medical Science and Peking Union Medical College Beijing 100050 PR China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2009年第20卷第8期

页      面：921-923页

核心收录：

学科分类：090403[农学-农药学(可授农学、理学学位）] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 070303[理学-有机化学] 0904[农学-植物保护] 0703[理学-化学] 

主　　题：Benzimidazole Coxsackie virus B3 (CVB3) Furan Anti-CVB3 activity 

摘      要：A series of novel benzimidazole derivatives was synthesized and their anti-Coxsackie virus B3 （CVB3） activity was evaluated in VERO ceils. Compounds 9 and 10 exhibited better inhibitory activity than those of ribavirin （RBV） with IC50 values of 5.30 and 1.06 μg/mL, respectively. ？2009 Xian Jin Luo. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.