Effect of bortezomib on migration and invasion in cervical carcinoma HeLa cell

作     者：Chong Shi Guo-Bin Zhang Shu-Wang Yin 

作者机构：Department of Genetic ReproductionMaternal and Child Health hospitalTangshan Department of GraduateHebei United University Pharmacy DepartmentAffiliated Hospital of North China Coal Medical University 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2015年第8卷第6期

页      面：484-487页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Tangshan City Science And Technology Research And Development Project(14130246a) 

主　　题：Bortezomib Cervical carcinoma HeLa cell Migration Invasion Akt/mTOR signal pathway 

摘      要：Objective:To explore the effect of bortezomib on migration and invasion of cervical carcinoma HeLa cell and specific molecular ***:The effect of bortezomib on the viability of HeLa cell was measured by MTT *** effect of bortezomib on cell migration and invasion was measured by Transwell assay and invasion experiment *** activation of Akt/mTOR signaling pathway and expression level of MMP2,MMP9 were assayed by western ***:MTT assay indicated bortezomib(2.5 μM.5 μM,10 μM)could inhibit HeLa cell viability,and the inhibitory rate was highest at 48 *** assay and invasion experiment results showed that bortezomib inhibited HeLa cell migration and *** blotting assays presented bortezomib could suppress the phosphorylation of Akt and *** down-regulate the expression of MMP2 and ***:These results suggested bortezomib could inhibit migration and invasion in cervical carcinoma HeLa cell,which might be related to Akt/mTOR signal pathway.