Synthesis and theoretical study of first generation CCK-functional dendrimers

作     者：Gu He Li Guo 

作者机构：Key Laboratory of Drug Targeting of Ministry of Education and Department of Medicinal Chemistry West China School of Pharmacy Sichuan University Chengdu 610041 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2007年第18卷第12期

页      面：1505-1508页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：National Natural Science Foundation of China  NSFC  (20472055) 

主　　题：Dendrimer CCK Synthesis Molecular mechanics Semi-empirical molecular orbital theory 

摘      要：A convenient synthesis and theoretical study of five CCK-functional dendrimers is described. The dendritic cores were linked with the CCK（Trp-Met-Asp（OBn）-PheNH2） fragment by forming amide bonds to give five target molecules. The structures of CCK-functional dendrimers were characterized by NMR, MS spectrum and predicted using molecular mechanics and PM3 semi- empirical molecular orbital theory.