Resveratrol inhibits collagen Ⅰ synthesis by suppressing IGF-1R activation in intestinal fibroblasts

作     者：Ping Li Mei-Lan Liang Ying Zhu Yao-Yao Gong Yun Wang Ding Heng Lin Lin 

作者机构：Department of GastroenterologyFirst Affiliated Hospital of Nanjing Medical University Nanping First Hospital Affiliated to Fujian Medical University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第16期

页      面：4648-4661页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China,No.81270462 the International Cooperation Project of Jiangsu Province Department of Health,No.SBZ201100103 

主　　题：Intestinal fibrosis Insulin-like growth factor-1 Resveratrol Silent information regulator 1 Fibroblasts 

摘      要：AIM: To investigate whether resveratrol (3,4,5-trihydroxy-trans-stilbene) inhibits collagen I synthesis induced by insulin growth factor-1 (IGF-1) in intestinal fibroblasts, and to explore the possible molecular mechanisms.