Enantioselective Total Synthesis of Four Styrylpyrone Derivatives

作     者：Xiao Shui PENG An Pai LI Tong Xing WU Xin Fu PAN 

作者机构：Department of Chemistry&National Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000 

出 版 物：《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期：2002年第13卷第6期

页      面：519-520页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：We are grateful to the National Natural Science Foundation of China(No.2017223)for financial support 

主　　题：Enantioselective 5-acetoxygoniothalamin 5-acetoxyisogoniothalamin oxide 6R-(+)- goniothalamin (6R, 7R, 8R)-(+)-goniothalamin oxide. 

摘      要：The first enantioselective total synthesis of 5-acetoxygoniothalamin 1 and 5-acetoxyisogoniothalamin oxide 2 was achieved through the Sharpless kinetic resolution of racemic secondary 2- furylmethanol 5 and the Mitsunobu reaction. At the same time we developed a short synthetic route for 6R-(+)-goniothalamin 3 and (6R, 7R, 8R)-(+)-goniothalamin oxide 4. And according to this route the configuration of 5-acetoxygoniothalamin 1 was confirmed as (5S, 6S).