Platelet to lymphocyte ratio as a novel prognostic tool for gallbladder carcinoma
Platelet to lymphocyte ratio as a novel prognostic tool for gallbladder carcinoma作者机构：Department of Hepatobiliary Surgerythe First Affiliated Hospital of Medical CollegeXi’an Jiaotong University
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2015年第21卷第21期
页 面：6675-6683页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Hospital Foundation of the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine(Xi’an,China),No.2013YK36 National Natural Science Foundation of China,No.81272644 and No.81072051(to Liu C)
主 题：Platelets Lymphocyte Gallbladder carcinoma Prognosis Survival
摘 要：AIM:To preliminarily investigate the prognostic significance of the platelet to lymphocyte ratio(PLR) in patients with gallbladder carcinoma(GBC).METHODS:Clinical data of 316 surgical GBC patients were analyzed retrospectively,and preoperative serum platelet and lymphocyte counts were used to calculate the *** optimal cut-off value of the PLR for detecting death was determined by the receiver operating characteristic(ROC) *** primary outcome was overall survival,which was estimated by the Kaplan-Meier *** log-rank test was used to compare the differences in ***,we conducted multivariate Cox analysis to assess the independent effect of the PLR on the survival of GBC ***:For the PLR,the area under the ROC curve was 0.620(95%CI:0.542-0.698,P = 0.040) in detecting *** cut-off value for the PLR was determined to be 117.7,with 73.6% sensitivity and 53.2% *** PLR was found to be significantlypositively correlated with CA125 serum level,tumornode-metastasis(TNM) stage,and tumor *** analysis identified carcinoembryonic antigen(CEA),CA125 and CA199 levels,PLR,TNM stage,and the degree of differentiation as significant prognostic factors for GBC when they were expressed as binary *** analysis showed that CA125 35 U/mL,CA199 39 U/mL,PLR ≥ 117.7,and TNM stage Ⅳ were independently associated with poor survival in *** expressed as a continuous variable,the PLR was still an independent predictor for survival,with a hazard ratio of 1.018(95%CI:1.001-1.037 per 10-unit increase,P = 0.043).CONCLUSION:The PLR could be used as a simple,inexpensive,and valuable tool for predicting the prognosis of GBC patients.
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