The gain of hydrogen peroxide resistance benefits growth fitness in mycobacteria under stress
The gain of hydrogen peroxide resistance benefits growth fitness in mycobacteria under stress作者机构：CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology CAS Beijing 100101 China University of Chinese Academy of Sciences Beijing 100082 China School of Life Sciences Tsinghua University Beijing 100084 China School of Life Sciences China Agriculture University Beijing 100094 China Beijing Key Laboratory of Drug Resistance and Resistome Beijing 100101 China
出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)
年 卷 期：2014年第5卷第3期
页 面：182-185页
核心收录：
学科分类：090603[农学-临床兽医学] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0906[农学-兽医学]
基 金：the Key Program of the Chinese Academy of Sciences 国家自然科学基金 supported by the National Basic Research Program (973 Program)
主 题：hydrogen peroxide resistance benefits formidable challenge global health
摘 要：Dear Editor, Tuberculosis （TB） is a formidable challenge to global health and is caused by an ancient pathogen, Mycobacteriurn tuberculosis （WHO, 2010）. In the pre-antibiotic era, TB killed 20% of adults in Europe and North America in the period from the seventeenth to the nineteenth centuries （Wilson, 2005）. Since antibiotics have been included in TB treatment regi- mens, millions of human lives have been saved by this che- motherapy. However, the standard anti-tuberculosis therapy is only effective for drug-susceptible TB but not for multi-drug resistant and extensively drug-resistant TB. Unfortunately, our knowledge of drug resistance in mycobacteria remains unclear and thus hampers the development of new anti- tubercular drugs. The basic mechanisms of drug resistance in mycobacteria are complicated and the outcome of drug resistance stems from evolution in the final analysis. Under- standing the evolutionary strategies used by M. tuberculosis might give new insights into designing control strategies against M. tuberculosis （Little et al,. 2012）.
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