Epidemiology and Mutational Analysis of Global Strains of Crimean-Congo Haemorrhagic Fever Virus

作     者：Simon Rayner 

作者机构：Bioinformatics GroupState Key Laboratory for VirologyWuhan Institute of VirologyChinese Academy of Sciences 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2011年第26卷第4期

页      面：229-244页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Crimean-Congo hemorrhagic fever virus (CCHFV) Epidemiology Mutational Analysis 

摘      要：Crimean-Congo hemorrhagic fever (CCHF) is a severe illness with high *** are reported in several countries in Africa,Europe,the Middle East,and *** analyses based on the virus S (nucleocapsid),M (glycoprotein),and L (polymerase) genome segments sequences indicate distinct geographic lineages exist but their specific genetic characteristics require *** this work we collected all full length S segment sequences and generated a phylogenetic tree based on the alignment of these 62 *** then analyzed the alignment using entries from AAIndex,the Amino Acid Index database,to identify amino acid mutations that performed significant changes in charge,pka,hydropathy and side chain ***,we mapped these changes back to the tree and alignment to identify correlated mutations or sites that characterized a specific *** on this analysis we are able to propose a number of sites that appear to be important for virus function and which would be good candidates for experimental mutational analysis studies.