Role of fibroblast growth factor receptor 1 in the bone development and skeletal diseases

作     者：李福兵 杜晓岚 陈林 

作者机构：State Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterInstitute of Surgery Re-search.Duping Hospital.Third Military Medical University 

出 版 物：《Journal of Medical Colleges of PLA(China)》 (中国人民解放军军医大学学报（英文版）)

年 卷 期：2007年第22卷第6期

页      面：376-384页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：the National Key Basic Research and Devel opment Plan of China(973 Projects,2005CB522604) the Research Project of Scientific Committee of Chongqing(2004BA5016) 

主　　题：fibroblast growth factor receptor 1 bone development skeletal disease conditional inactivation bone fracture 

摘      要：Accumulating data suggest that FGFs/FGFR1 plays essential roles in the bone development and human skeletal diseases. Conditional inactivation of fgfrl caused different phenotypes displaying in different cells or specific organs and revealed some novel functions of FGFR1 in bone development. Fgfrl mutation mainly induced 2 types of human skeletal diseases, craniosynostosis syndrome and dysplasias. Similar mutation of fgfrl in mouse model just mimicked the phenotype that happened in human. These fa- cilitate the investigation on the underlying mechanism of the diseases. Here we mainly focused on the ad- vance of FGFR1 function in the bone development and its mutation caused skeletal diseases.