Evaluation of liver tissue by polymerase chain reaction for hepatitis B virus in patients with negative viremia

作     者：Fouad Thakeb Magdy El-Serafy Soheir Zakaria Bahaa Monir Sahar Lashin Raghda Marzaban Mostafa El-Awady 

作者机构：Tropical Medicine Department Pathology Department Department of Biomedical Technology 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2005年第11卷第43期

页      面：6853-6857页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Hepatitis B in situ Antiviral therapy HBVDNA Chronic hepatitis 

摘      要：AIM: To assess the clinical significance of Hepatitis B virus (HBV) DNA localization in the liver tissue of patients with positive HBsAg and negative ***: HBV virological parameters of 33 HBsAg positive chronic hepatitis patients, including seromarkers and HBV DNA amplification in both sera and liver biopsies, were ***: Ten patients had negative viremia and positive HBV DNA in their liver biopsies. Most of them had HBeAg-negative/HBeAb-positive chronic *** liver biochemical and histopathological profiles were different from the viremic patients. Their disease pattern was designated as hepatitis B in situ .CONCLUSION: Hepatitis B in situ is a consequential entity which can be missed in clinical practice. It is a new clinical pattern of chronic HBV infection that considers HBV in liver biopsy and adds a new indication for antiviral therapy.