循环饥饿激素加速糖尿病胃轻瘫患者胃排空:一项双盲、安慰剂、对照、交叉研究
Ghrelin enhances gastric emptying in diabetic gastroparesis: A double blind, placebo controlled, crossover study作者机构：Physiology Unit St. Mark‘s Hospital Harrow HA1 3UJ United KingdomDr.
出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)
年 卷 期：2006年第2卷第4期
页 面：40-40页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：糖尿病胃轻瘫 饥饿激素 安慰剂对照 胃排空率 交叉研究 实时超声显像 术后肠梗阻 迷走神经损伤 致残
摘 要：Background: Diabetic gastroparesis is a disabling condition with no consistently effective treatment. In animals, ghrelin increases gastric emptying and reverses postoperative ileus. We present the results of a double blind, placebo controlled, crossover study of ghrelin in gastric emptying in patients with diabetic gastroparesis. Methods: Ten insulin requiring diabetic patients (fivemen, six type I) referred with symptoms indicative of gastroparesis received a two hour infusion of either ghrelin (5 pmol/kg/min) or saline on two occasions. Blood glucose was control led by euglycaemic clamp. Gastric emptying rate (GER) was calculated by real tim e ultrasound following a test meal. Blood was sampled for ghrelin, growth hormon e (GH), and pancreatic polypeptide (PP) levels. Cardiovagal neuropathy was asses sed using the Mayo Clinic composite autonomic severity score (range 0 (normal)- 3). Results: Baseline ghrelin levels were mean 445 (SEM 36) pmol/l. Ghrelin infu sion achieved a peak plasma level of 2786 (188) pmol/l at 90 minutes, correspond ing to a peak GH of 70.9 (19.8) pmol/l. Ghrelin increased gastric emptying in se ven of 10 patients (30 (6)%to 43 (5)%; p = 0.04). Impaired cardiovagal tone co rrelated inversely with peak postprandial PP values (p 0.05) but did not corre late with GER. Conclusions: Ghrelin increases gastric emptying in patients with diabetic gastroparesis. This is independent of vagal tone. We propose that analo gues of ghrelin may represent a new class of prokinetic agents.
维普期刊数据库
同方期刊数据库