LncRNA PU.1 AS regulates arsenic-induced lipid metabolism through EZH2/Sirt6/SREBP-1c pathway

作     者：Zheng Dong Changying Li Chunyang Yin Ming Xu Sijin Liu Ming Gao 

作者机构：State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China University of Chinese Academy of Sciences Beijing 100049 China Liver Research Center Beijing Friendship Hospital Capital Medical University Beijing 100050 China 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2019年第31卷第11期

页      面：138-146页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 08[工学] 

基　　金：supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB14000000) the National Natural Science Foundation of China(Nos.21507154,21425731,21637004 and 81570542) 

主　　题：Arsenic Lipid metabolism LncRNA PU.1 AS SREBP-1c 

摘      要：Arsenic (As) is an omnipresent metalloid toxicant,which has elicited serious environmental pollution and health risky *** studies have uncovered that the As exposure could also cause markedly reduction of serum triglycerides in ***,the regulation mechanisms are still largely *** present study is aimed to elucidate the molecular mechanisms of lncRNAs in As-induced lipid metabolic *** demonstrated that lncRNA PU.1 AS was significantly induced in the liver of As-feed mice companied with lower serum triglycerides contents;further in vitro experiment confirmed that PU.1 AS regulated liver cells lipid accumulation by nile red fluorescence *** mechanistic investigations illustrated that PU.1 AS could interact with EZH2 protein to regulate its downstream target gene expression,and Asinduced PU.1 AS attenuated EZH2-supppressed Sirt6 expression,thereafter leading to a decreased SREBP-1c protein expression,as well as the diminished synthesis of triglycerides in *** conclusion,this study provided a new lncRNA-related regulatory signaling pathway participating in As-induced abnormal lipid metabolism.