Single dose of intra-muscular platelet rich plasma reverses the increase in plasma iron levels in exercise-induced muscle damage:A pilot study

作     者：Zekine Punduk Onur Oral Nadir Ozkayin Khalid Rahman Rana Varol 

作者机构：Department of Physical Education and Sports University of Balikesir Balikesir 10100 Turkey Department of Physical Education and Sports University of Ege Izmir 35040 Turkey Medical Faculty Department of Orthopaedics and Traumatology University ofEge Izmir 35100 Turkey Faculty of Science Schooi of Pharmacy and Biomolecular Sciences Liverpool John Moores University Liverpool L3 3AE UK 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2016年第5卷第1期

页      面：109-114页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 04[教育学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 

主　　题：Exercise induced muscle damage Ferritin Plasma iron Platelet rich plasma 

摘      要：Background:Platelet rich plasma(PRP) therapy is widely used in enhancing the recovery of skeletal muscle from ***,the impact of intramuscular delivery of PRP on hematologic and biochemical responses has not been fully elucidated in exercise-induced muscle *** purpose of this investigation the effects of intramuscular delivery of PRP on hematologic and biochemical responses and recovery strategy muscle damage induced by high intensity muscle exercise(exercise-induced muscle damage,EIMD).Methods:Moderately active male volunteers participated in this study and were assigned to a control group(control,n = 6) and PRP administration group(PRP,n = 6).The subjects performed exercise with a load of 80% one repetition maximum(1RM) maximal voluntary contraction of the elbow flexors until point of exhaustion of the non-dominant arm was *** arms were treated with saline or autologous PRP post-24 h *** blood samples were obtained in the morning to establish a baseline value and 1–4 days post-exercise and were analyzed for serum ferritin,iron,iron binding capacity(IBC),creatinine kinase(CK),lactate dehydrogenase(LDH),aspartate aminotransferase(AST),and alanine aminotransferase(ALT).Results:The baseline levels of plasma iron,ferritin,IBC,CK,LDH,AST,and ALT were similar in both the control and PRP ***,24-h following exercise a significant increase in these parameters was observed in both groups between 1 and 4 days during the recovery ***,PRP administration decreased plasma iron levels compared to the control on the second day *** IBC increased in PRP group from Days 2 to 4 post-exercise compared to the control group whilst PRP administration had no effect on plasma ferritin,CK,AST,ALT,or ***:Acute exhaustive exercise increased muscle damage markers,including plasma iron,IBC,and ferritin levels,indicating muscle damage induced by *** administration improves inflammation by reversing th