Hypofractionated particle beam therapy for hepatocellular carcinoma–a brief review of clinical effectiveness

作     者：Che-Yu Hsu Chun-Wei Wang Ann-Lii Cheng Sung-Hsin Kuo 

作者机构：Division of Radiation OncologyDepartment of OncologyNational Taiwan University Hospital and National Taiwan University College of MedicineTaipei 100Taiwan National Taiwan University Cancer CenterNational Taiwan University College of MedicineTaipei 100Taiwan Cancer Research CenterNational Taiwan University College of MedicineTaipei 100Taiwan Department of Internal Medicine and Department of OncologyNational Taiwan University HospitalTaipei 100Taiwan Graduate Institute of OncologyNational Taiwan University College of MedicineTaipei 100Taiwan 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2019年第11卷第8期

页      面：579-588页

核心收录：

学科分类：10[医学] 

基　　金：Supported by the Ministry of Science and Technology,Taiwan,No.MOST 107-2314-B-002-217-MY3 National Taiwan University Hospital,Taiwan,No.NTUH 108-S4143 

主　　题：Hepatocellular carcinoma Proton beam therapy Carbon ion radiotherapy Local control Toxicity Overall survival 

摘      要：Hepatocellular carcinoma(HCC)is the fifth most common malignancy and the second leading cause of cancer mortality *** cornerstone to improving the prognosis of HCC patients has been the control of loco-regional disease progression and the lesser toxicities of local *** radiotherapy has not been considered a preferred treatment modality for HCC,charged particle therapy(CPT),including proton beam therapy(PBT)and carbon ion radiotherapy(CIRT),possesses advantages(for example,it allows ablative radiation doses to be applied to tumors but simultaneously spares the normal liver parenchyma from radiation)and has emerged as an alternative treatment option for *** the technological advancements in CPT,various radiation dosages of CPT have been used for HCC treatment via ***,the efficacy and safety of the evolving dosages remain *** assess the association between locoregional control of HCC and the dose and regimen of CPT,we provide a brief overview of selected literature on dose regimens from conventional to hypofractionated short-course CPT in the treatment of HCC and the subsequent determinants of clinical ***,CPT provides a better local control rate compared with photon beam therapy,ranging from 80%to 96%,and a 3-year overall survival ranging from 50%to 75%,and it results in rare grade 3 toxicities of the late gastrointestinal tract(including radiation-induced liver disease).Regarding CPT for the treatment of locoregional HCC,conventional CPT is preferred to treat central tumors of HCC to avoid late toxicities of the biliary *** contrast,the hypo-fractionation regimen of CPT is suggested for treatment of larger-sized tumors of HCC to overcome potential radio-resistance.