Reliable screening of pesticide residues in maternal and umbilical cord sera by gas chromatography-quadrupole time of flight mass spectrometry

作     者：FAN RuoJing ZHANG Fang WANG HaoYang ZHANG Li ZHANG Jing ZHANG Ying YU ChongTian GUO YinLong 

作者机构：Shanghai Mass Spectrometry CenterShanghai Institute of Organic Chemistry Chinese Academy of Sciences Department of Gynaecology and Obstetrics Yijishan Hospital of Wannan Medical College Agilent Technologies (China) CO. Ltd. 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2014年第57卷第5期

页      面：669-677页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：supported by the Science and Technology Commission of Shanghai Municipality(13ZR1448100) 

主　　题：pesticide residues screening maternal and umbilical cord sera gas chromatography-quadrupole time of flight massspectrometry 

摘      要：The widespread use of pesticides induces heavy adverse effects on human health,especially for the pregnant women and the *** this study,a screening method has been developed for the determination of multi-pesticides in maternal and umbilical cord *** pesticides in sera were collected using solid phase extraction(SPE),and analyzed by gas chromatography-quadrupole time of flight mass spectrometry(GC-QTOF MS).To set up the quality criteria,a database of 50 pesticides was created and the accurate masses of 3 up to 5 representative ions with their intensity ratios were included for each *** addition,a novelidentification points(IPs)system relying on the accurate MS1 and MS2 spectra was used to interpret the data for each suspected *** methodology was then applied to a pair of maternal and umbilical cord sera.A total of six pesticide residues were screened out *** conclusion,GC-QTOF MS combined with an accurate mass database seemed to be one of the most efficient tools for systematic pesticide analysis.