Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment

作     者：TIAN Ai-ping YIN Yu-kun YU Lei YANG Bo-yan LI Ning LI Jian-ying BIAN Zhi-min HU Shang-ying WENG Chun-xiao FENG Li TIAN Ai-ping;YIN Yu-kun;YU Lei;YANG Bo-yan;LI Ning;LI Jian-ying;BIAN Zhi-min;HU Shang-ying;WENG Chun-xiao;FENG Li

作者机构：Department of Traditional Chinese MedicineNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing(100021)China Department of Comprehensive TherapyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing(100021)China Department of Cancer EpidemiologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing(100021)China Beijing Chiamery Medical Sciences InstituteBeijing(100080)China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2020年第26卷第4期

页      面：263-269页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supoorted by the Fund for Beijing Scienee&Technology Development of TCM(No.JJ2015-65) 

主　　题：malignant pleural effusion low-frequency ultrasonic penetration Chinese medicine randomized con trolled trial 

摘      要：Objective:To evaluate whether low-frequency ultrasound-facilitated transdermal delivery of a Chinese medicine(CM)formula could improve the efficacy of intrapleural administration of interleukin?2(IL-2)in treatment of malignant pleural effusion(MPE).Methods:A total of 110 eligible participants were randomized into the low-frequency sonophoresis(LFS)of CM(LSF/CM)group(55 cases)and the control group(55 cases)by simple randomization using a random number *** control group was treated with an intrapleural administration of IL-2;and the LFS/CM group was treated with LFS of a CM gel formulation,combined with the same IL-2 injection as in the control *** CM formula consisted of Semen Lepidii,Semen Sinapis,Flamulus Cinnamomi,Poriacocos,Herba Lycopi,and Radix Paeoniae *** 2-week treatment,the therapeutic outcome was determined by the change of the amount of MPE,which was evaluated by B-scan ultrasound and/or chest X-ray,and the change of quality of life(QOL)scores,which were evaluated by the Eastern Cooperative Oncology Group(ECOG)performance ***:A significantly higher objective remission rate(ORR)was obtained with intrapleural IL-2 plus LFS/CM than IL-2 treatment alone(P=0.049).In addition,more patients in the LFS/CM group than in the control group had an improved QOL score(P=0.048),and no patients in the LFS/CM group had a reduced ***:LFS of CM formulation could effectively alleviate MPE and improve the QOL of cancer patients.