心率恢复在心力衰竭患者中的预后预测价值

作     者：Arena R. Guazzi M. Myers J. Peberdy M.A. 杨海涛 

作者机构：Department of Physical TherapyVirginia Commonwealth UniversityHealth SciencesCampusRichmondVA23298-0224United States.Dr 

出 版 物：《世界核心医学期刊文摘（心脏病学分册）》 (Digest of the World Core Medical Journals(Cardiology))

年 卷 期：2006年第2卷第9期

页      面：16-16页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：运动后心率恢复 心力衰竭患者 预测价值 预后 心肺运动试验 Cox回归分析 平均年龄 每分钟通气量 

摘      要：Background: The rate in which heart rate recovers from exercise has recently been shown to be a strong predictor of mortality in patients suspected of having coronary disease, but its prognostic value in patients with heart failure(HF) has not been explored. We sought to assess the prognostic utility of heart rate recovery(HRR) in patients with HF. Methods: Eighty-seven subjects diagnosed with compensated HF underwent cardiopulmonary exercise testing(CPX). Mean age and ejection fraction were 50.0(±13.9) years and 28.1%(±13.6%), respectively. Heart rate at 1-minute post-CPX was subtracted from maximal heart rate during the exercise test to produce a measure of HRR1 in beats per minute. Subjects were followed for a combined death/hospitalization end point for 1-year after CPX. Results: The mean peak respiratory exchange ratio, peak oxygen consumption(Vo2), minute ventilation/carbon dioxide production(VE/Vco2) slope, and HRR1 were 1.06(±0.11), 14.8(±4.7)mL·kg-1·min-1, 36.6(±8.6), and 11.0(±10.4) beat/min, respectively. Although all three variables were significant univariate predictors of the composite end point(P