A clinical study to determine the threshold of bronchodilator response for diagnosing asthma in Chinese children

作     者：Xiao-Hui Kang Wan Wang Ling Cao 

作者机构：Children's Hospital Affiliated to the Capital Institute of PediatricsNo.2 Ya bao RoadChaoyang DistrictBeijingChina Shanxi Provincial Children's HospitalTaiyuanChina 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2019年第15卷第6期

页      面：559-564页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study was supported by the Merck Investigator Studies Program 

主　　题：Asthma diagnosis Bronchodilator response Threshold 

摘      要：Background There is few objective,clinically feasible and inexpensive test for diagnosing childhood *** want to find an ideal way to solve *** The control group was 301 non-asthmatic children,and the asthma group was 286 asthmatic *** asthmatic children were divided into three groups according to the severity of their ***-and post-bronchodilator spirometer tests were performed,and the main spirometer parameters were *** bronchodilator response(BDR)[BDR is used to determine the reversibility of airway obstruction by measuring the changes of forced expiratory volume in the first second(FEV1)before and after inhalation of bronchodilators]was then determined,and the optimal threshold of BDR for diagnosing childhood asthma was *** 301 non-asthmatic children and 286 asthmatic children participated in the study,the demographics were *** 1 for pre-bronchodilator of asthmatic children was significantly lower than that of non-asthmatic children(P≤0.01).BDR of non-asthmatic children was 3.30±3.85%.BDR of asthmatic children was 9.45±9.15%.There was no significant difference in BDR for patients with different severities of asthma within the *** had no statistical correlation with gender,age,height,weight in neither non-asthmatic children nor asthmatic *** the receiver-operating characteristic curve,a BDR threshold of≥7.5%offered an optimal balance in asthma diagnosis with a sensitivity rate of 50.7%and specificity rate of 87.7%.Meanwhile,with a BDR threshold of≥12%,the sensitivity rate was 28.7%and the specificity rate was 96.3%.Conclusion A BDR threshold of≥7.5%has more value in childhood asthma diagnosis as compared to≥12%.