Cardiac tissue-derived extracellular matrix scaffolds for myocardial repair:advantages and challenges

作     者：Pawan KC Yi Hong Ge Zhang 

作者机构：Department of Biomedical EngineeringThe University of AkronOlson Research CenterRoom 301L260 S Forge StreetAkronOH 44325USA Department of BioengineeringUniversity of Texas at Arlington500 UTA BlvdRoom 240ArlingtonTX 76019USA 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2019年第6卷第4期

页      面：185-199页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 

基　　金：the National Institutes of Health(1R15HL122949 to G.Z.,1R15HL140503 to Y.H.) the American Heart Association(19AIREA34400087 to G.Z.) 

主　　题：myocardial infarction decellularized extracellular matrix scaffold cardiac tissue engineering 

摘      要：Decellularized extracellular matrix(dECM)derived from myocardium has been widely explored as a nature scaffold for cardiac tissue engineering *** dECM offers many unique advantages such as preservation of organ-specific ECM microstructure and composition,demonstration of tissue-mimetic mechanical properties and retention of biochemical cues in favor of subsequent ***,current processes of dECM decellularization and recellularization still face many challenges including the need for balance between cell removal and extracellular matrix preservation,efficient recellularization of dECM for obtaining homogenous cell distribution,tailoring material properties of dECM for enhancing bioactivity and prevascularization of thick *** review summarizes the recent progresses of using dECM scaffold for cardiac repair and discusses its major advantages and challenges for producing biomimetic cardiac patch.