The Role of Non-Coding RNA in Vascular Remodeling Induced by Mechanical Stress

作     者：Yingxin Qi 

作者机构：Institute of Mechanobiology& Medical EngineeringSchool of Life Sciences &BiotechnologyShanghai Jiao Tong University School of Biological Science and Medical EngineeringBeihang University 

出 版 物：《医用生物力学》 (Journal of Medical Biomechanics)

年 卷 期：2019年第34卷第A1期

页      面：21-22页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China ( 11625209 11572199 31670958) 

主　　题：Non-Coding RNA Vascular Remodeling Induced Mechanical Stress RNA 

摘      要：Vascular remodeling is the essential pathogenic process of various cardiovascular disorders,including hypertension,atherosclerosis,stroke,and restenosis after vein *** main characterization of vascular remodeling is abnormal variations of vascular cell phenotype,morphological structure and functions such as migration,hypertrophy,proliferation and *** researches revealed that mechanical stress,including shear stress and cyclic stretch,participates in physiological vascular homeostasis,or pathophysiological vascular *** understanding of mechanobiological mechanism in vascular remodeling will play a unique role in understanding human physiology and disease,and will generate important theoretical and clinical significance [2].Non-coding RNAs are newly recognized RNAs which cannot be translated into proteins but are involved in epigenetic modification of gene *** studies revealed that non-coding RNAs,such as microRNAs(miRNAs)and long noncoding RNAs(long ncRNAs,IncRNA),as well as small interfering RNAs(siRNAs),piwi-interacting RNAs(piRNAs),small nucleolar RNAs(snoRNAs),play essential roles in the regulation of various processes,such as metabolism,development,cell proliferation,cell apoptosis,cell differentiation,oncogenesis and vascular homeostasis[5].However,the roles of non-coding RNAs in the cardiovascular system under mechanical stresses are still not *** recent researches detected the mechanical regulation of IncRNAs and miRNAs in vascular *** are non-protein-coding transcripts that are longer than 200 nucleotides(nt),which is an arbitrary cut-off value that distinguishes these transcripts from other small *** the well-established mechanism of microRNA action,the functional mode of IncRNAs is not fully *** evidence shows that IncRNAs modulate gene expression via a multilevel-regulated *** their large number and complicated functional modes,lncRNAs are emerging as i