Role of cortical spreading depression in the pathophysiology of migraine

作     者：Yilong Cui Yosky Kataoka Yasuyoshi Watanabe 

作者机构：Division of Bio-function Dynamics ImagingRIKEN Center for Life Science Technologies6-7-3 Minatojima minamimachiChuo-kuKobeHyogo 650-0047Japan 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2014年第30卷第5期

页      面：812-822页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported in part by a consignment expense from the Molecular Imaging Program on "Research Base for Exploring New Drugs" KAKENHI(24659574) from the Ministry of Education,Culture,Sports,Science,and Technology(MEXT) of the Government of Japan 

主　　题：cortical spreading depression migraine neurogenic inflammation PET trigeminal nociceptive pathway 

摘      要：A migraine is a recurring neurological disorder characterized by unilateral, intense, and pulsatile headaches. In one-third of migraine patients, the attacks are preceded by a visual aura, such as a slowly-propagating scintillating scotoma. Migraine aura is thought to be a result of the neurovascular phenomenon of cortical spreading depression （SD）, a self-propagating wave of depolarization that spreads across the cerebral cortex. Several animal experiments have demonstrated that cortical SD causes intracranial neurogenic inflammation around the meningeal blood vessels, such as plasma protein extravasation and pro-inflammatory peptide release. Cortical SD has also been reported to activate both peripheral and central trigeminal nociceptive pathways. Although several issues remain to be resolved, recent evidence suggests that cortical SD could be the initial trigger of intracranial neurogenic inflammation, which then contributes to migraine headaches via subsequent activation of trigeminal afferents.