Roles of Regulatory T Cells in Pathogenesis of Endometriosis

作     者：Xin-Xin Hou Xiao-Qiu Wang Da-Jin Li 

作者机构：Laboratory for Reproductive ImmunologyKey Laboratory of Reproduction Regulation of NPFPCSIPPRShanghaiChina Laboratory for Reproductive ImmunologyShanghai Key Laboratory of Female Reproductive Endocrine Related DiseasesHospital and Institute of Obstetrics and GynecologyIRDFudan University Shanghai Medical CollegeShanghaiChina 

出 版 物：《Reproductive and Developmental Medicine》 (生殖与发育医学（英文版）)

年 卷 期：2019年第3卷第2期

页      面：117-123页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Endometrial Stromal Cells Endometriosis Fibrinogen-Like Protein 2 Regulatory T Cells 

摘      要：Numerous studies have shown aberrant immune cell function in endometriosis,including T cells,B cells,natural killer cells,and macrophages(MΦ).These alterations are thought to be induced by various mechanisms that promote the *** T cells(Tregs)may account for a decreased ability of newly recruited leukocytes to initiate effective immune responses against viable endometrial fragments,permitting their *** differentiate during the development of endometriosis,which confer immunosuppression or play other roles in disease *** this review,we provide an overview of the regulation and roles of Tregs in *** data provide further scientific evidence for the altered immune response in endometriosis,which could be a potential target in the treatment of *** review could create new diagnostic strategies and effective immune-targeted therapies for this highly prevalent *** progress in the field indicates that these goals may be achieved in the future.