Silver-catalyzed three-component reaction: synthesis of N^2-substituted 1,2,3-triazoles via direct benzylic amination

作     者：Zhenhua Liu Wenjing Hao Wen Gao Guangyu Zhu Xiang Li Lili Tong Bo Tang 

作者机构：College of ChemistryChemical Engineering and Materials ScienceCollaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongKey Laboratory of Molecular and Nano ProbesMinistry of EducationShandong Provincial Key Laboratory of Clean Production of Fine ChemicalsShandong Normal University 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2019年第62卷第8期

页      面：1001-1006页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China (21535004, 91753111, 21605097, 21775092, 21390411) the Key Research and Development Program of Shandong Province (2018YFJH0502) the Natural Science Foundation of Shandong Province of China (ZR2016BQ01, ZR2018JL008) the China Postdoctoral Science Foundation (2017M610442) 

主　　题：silver-catalyzed alkynes 1,2,3-triazoles amination 

摘      要：A novel Ag(Ⅰ)-catalyzed benzylic amination reaction with in situ generation of NH-1,2,3-triazoles for N^2-substituted 1,2,3 triazole scaffolds is described. This protocol is achieved with easily accessible substrate, broad functional group, good re gioselectivity, thus providing the efficient and practical method to diverse N^2-substituted 1,2,3-triazole rings with moderate t good yields.