药物引起的高敏症状与巨细胞病毒再激活有关:致病T细胞的免疫学特征
Drug-induced hypersensitivity syndrome associated with cytomegalovirus reactivation:Immunological characterization of pathogenic Tcells作者机构：Department of DermatologyHamamatsu Univ. School of Medicine120- 1 Handa-yama Hamamatsu 431- 3192Japan
出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)
年 卷 期：2005年第1卷第6期
页 面：39-40页
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
主 题：T细胞 免疫学特征 巨细胞病毒 三苄糖苷 皮肤浸润 缩氨酸 γ-干扰素
摘 要：We report a case of tribenoside- induced hypersensitivity syndrome associated with cytomegalovirus reactivation and investigation of the immunological characteristics of the circulating and skin- infiltrating lymphocytes. Activated CD8+ T cells outnumbered CD4+ cells in both the circulation and the skin lesions. Upon in vitro stimulation with the drug, CD4+ cells proliferated and produced interferon-γ .The circulating CD8+ cells used limited T-cell receptor V β s, some of which are restricted to cytomegalovirus-derived peptide in the context of the HLA- A2 haplotype. CD8+ cells and cytomegalovirus-containing cells closely co-localized in the skin lesions. These results suggested that CD4+ cells were drug-reactive, whereas cytomegalovirus activated CD8+ cells in the present case. These two cell types seemed to play a distinct role in drug-induced hypersensitivity syndrome.
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