Oxidative C—H alkynylation of 3,6-dihydro-2H-pyrans

作     者：Ran Zhao Guidong Feng Xiaodong Xin Honghao Guan Jing Hua Renzhong Wan Wei Li Lei Liu 

作者机构：Department of Pharmaceutical Analysis School of Pharmacy Shandong University of Traditional Chinese Medicine Ji'nan 250355 China College of Animal Science and Veterinary Medicine Shandong Agricultural University Taian 271018 China School of Chemistry and Chemical Engineering Shandong University Ji'nan 250100 China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University Guilin 541004 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2019年第30卷第7期

页      面：1432-1434页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：financial supported by the National Natural Science Foundation of China (No. 21722204) Fok Ying Tung Education Foundation (No. 151035) the Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) (No. CHEMR2016-B09) Guangxi Funds for Distinguished expert 

主　　题：3,6-Dihydro-2H-pyrans C-H Functionalization Alkynylation Oxidation Organoborane 

摘      要：Current synthesis of α-substituted 3,6-dihydro-2H-pyrans dominantly relies on functional group transformation. Herein, a direct and practical oxidative C -H alkynylation and alkenylation of 3,6-dihydro-2H-pyran skeletons with a range of potassium trifluoroborates is developed. The metal-free process is well tolerated with a wide variety of 3,6-dihydro-2H-pyrans, rapidly providing a library of 2,4-disubstituted 3,6-dihydro-2H-pyrans with diverse patterns of α-functionalities for further diversification and bioactive small molecule identification.