咨询与建议

看过本文的还看了

相关文献

该作者的其他文献

文献详情 >Clinical characteristics of tw... 收藏

Clinical characteristics of two cohorts of infantile spasms: response to pyridoxine or topiramate monotherapy

Clinical characteristics of two cohorts of infantile spasms: response to pyridoxine or topiramate monotherapy

作     者:Jiao Xue Ping Qian Hui Li Ye Wu Hui Xiong Yue-Hua Zhang Zhi-Xian Yang 

作者机构:Department of PediatricsPeking University First HospitalNo.1Xi'anmen StreetXicheng DistrictBeijing 100034China 

出 版 物:《World Journal of Pediatrics》 (世界儿科杂志(英文版))

年 卷 期:2018年第14卷第3期

页      面:290-297页

核心收录:

学科分类:1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基  金:supported by grants from Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases 

主  题:Infantile spasms Pyridoxine Topiramate 

摘      要:Background Infantile spasms (IS) was an epileptic disease with varied treatment widely among clinicians. Here, we aimed to compare and analyze the clinical characteristics of IS response to pyridoxine or topiramate monotherapy (TPM control IS). Methods The clinical manifestations, treatment processes and outcomes were analyzed in 11 pyridoxine responsive IS and 17 TPM-control IS. Results Of the 11 patients with pyridoxine responsive IS, nine were cryptogenic/idiopathic. Age of seizure onset was 5.36 ± 1.48 months. Spasms were controlled within a week in most of the patients. At the last follow-up, EEG returned to normal in 8. Psychomotor development was normal in 6, mild delay in 3, severe delay in 2. Of the 17 patients with TPM-control IS, 10 were cryptogenic/idiopathic. The age of seizure onset was 5.58 ± 2.09 months. All patients were controlled within a month. At the last follow-up, EEG was normal in 10. Psychomotor development was normal in 8, mild delay in 5, severe delay in 4. Genetic analysis did not show any meaningful results. Conclusions The clinical characteristics and disease courses of pyridoxine responsive IS and TPM-control IS were similar, which possibly clued for a same pathogenic mechanism. Pyridoxine should be tried first in all IS patients, even in sympto-matic cases. If patients were not responsive to pyridoxine, TPM could be tried.

读者评论 与其他读者分享你的观点

用户名:未登录
我的评分