Gene redundancy and gene compensation:An updated view

作     者：Jinrong Peng Jinrong Peng

作者机构：College of Animal Sciences Zhejiang University 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2019年第46卷第7期

页      面：329-333页

核心收录：

学科分类：10[医学] 

基　　金：supported by National Key R&D Program of China (2018YFA0800501) National Natural Science Foundation of China (Nos.31571495, 31830113 and 31330050) 

主　　题：Gene redundancy Gene compensation Genetic compensation Non-sense-mediated RNA decay(NMD) COMPASS complex Genetic model system Zebrafish Capn3 Upf3a 

摘      要：Gene knockdown approaches using antisense oligo nucleotides or analogs such as siRNAs and morpholinos have been widely adopted to study gene functions although the off-target issue has been always a concern in these *** the other hand,classic genetic analysis relies on the availability of loss-offunction or gain-of-function *** fast development of genome editing technologies such as TALEN and CRISPR/Cas9 has greatly facilitated the generation of null mutants for the functional studies of target genes in a variety of organisms such as ***,an unexpected discrepancy was observed between morphant phenotype and mutant phenotype for many genes in zebrafish,i.e.,while the morphant often displays an obvious phenotype,the corresponding null mutant appears relatively normal or only exhibits a mild phenotype due to gene *** recent reports have partially answered this intriguing question by showing that a pre-mature termination codon and homologous sequence are required to elicit the gene compensation and the histone modifying complex COMPASS is involved in activating the expression of the compensatory ***,I summarize these exciting new progress and try to redefine the concept of genetic compensation and gene compensation.