Glioma associated microglia/macrophages, a potential pharmacological target to promote antitumor inflammatory immune response in the treatment of glioblastoma
Glioma associated microglia/macrophages, a potential pharmacological target to promote antitumor inflammatory immune response in the treatment of glioblastoma作者机构：Institute of PharmacologyUniversitàCattolica del S CuoreRome00168Italy Fondazione Policlinico Gemelli IRCCS00168RomeItaly
出 版 物：《Neuroimmunology and Neuroinflammation》 (神经免疫与神经炎症（英文版）)
年 卷 期：2018年第5卷第9期
页 面：2-14页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Glioblastoma macrophages microglia metalloproteases pro-inflammatory activation pro-tumor func-tions glioma associated microglia/macrophages targeted therapies pharmacotherapy
摘 要：Glioma associated microglia/macrophages (GAMs) constitute the largest proportion of glioma infiltrating cells, par-ticularly in high grade tumors (i.e., glioblastoma). Once inside the tumors, GAMs usually acquire a specific pheno-type of activation that favors tumor growth, angiogenesis and promotes the invasion of normal brain parenchyma. Therefore, treatments that limit or prevent GAMs recruitment at the tumor site or modulate their immune activa-tion promoting antitumor activities are expected to exert beneficial effects in glioblastoma. In the present paper, we aim at the revision of pharmacological strategies that interfere with GAMs function and are currently proposed as an alternative/additional option to current approved cytotoxic regimens.
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