Impact of LDB3 gene polymorphisms on clinical presentation and implantable cardioverter defibrillator(ICD) implantation in Chinese patients with idiopathic dilated cardiomyopathy

作     者：Dong-fei WANG Jia-lan LYU Juan FANG Jian CHEN Wan-wan CHEN Jia-qi HUANG Shu-dong XIA Jian-mei JIN Fang-hong DONG Hong-qiang CHENG Ying-ke XU Xiao-gang GUO 

作者机构：Department of Cardiologythe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Department of Cardiologythe Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Department of CardiologyPujiang Branch of the First Affiliated HospitalSchool of MedicineZhejiang UniversityJinhua 322200China Department of Pathology and PathophysiologySchool of MedicineZhejiang UniversityHangzhou 310058China Department of Cardiologythe Forth Affiliated HospitalSchool of MedicineZhejiang UniversityYiwu 322000China Key Laboratory of Biomedical Engineering of Ministry of EducationDepartment of Biomedical EngineeringZhejiang UniversityHangzhou 310027China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2019年第20卷第9期

页      面：766-775页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the Key Projects of Zhejiang Medical and Health Science and Technology Plan(Provincial and Ministerial Co-construction)(No.WKJ-ZJ-1819) the Fundamental Research Funds for the Zhejiang Province Universities(No.2019XZZX003-15) the National Natural Science Foundation of China(No.81470370) 

主　　题：Idiopathic dilated cardiomyopathy Implantable cardioverter defibrillator(ICD) LIM domain binding 3(LDB3) Polymorphism Han Chinese 

摘      要：Objective:Mutations in LIM domain binding 3(LDB3)gene cause idiopathic dilated cardiomyopathy(IDCM),a structural heart disease with a complicated genetic ***,the association of polymorphisms in the LDB3 gene with susceptibility to IDCM in Chinese populations remains unexplored as dose the impact on clinical ***:We sequenced all exons and the adjacent part of introns of the LDB3 gene in 159 Chinese Han IDCM patients and 247 healthy *** we detected the distribution of polymorphisms in the LDB3 gene in all participants and assessed their associations with risk of ***,we conducted a stratified genotype–phenotype correlation ***:The A allele of rs4468255 was significantly associated with IDCM(P0.01).The rs4468255,rs11812601,rs56165849,and rs3740346 were also associated with diastolic blood pressure(DBP)and left ventricular ejection fraction(LVEF)(P0.05).Notably,a higher frequency of rs4468255 polymorphism was observed in implantable cardioverter defibrillator(ICD)recipients under a recessive model(P0.01),whereas the significant association disappeared after adjusting for potential ***,in the dominant model,notable correlations could only be observed after adjusting for multi ***:The rs4468255 was significantly correlated with IDCM of Chinese Han population.A allele of rs4468255 is higher in IDCM patients with ICD implantation,suggesting the influence of genetic background in the generation of this *** addition,rs11812601,rs56165849,and rs3740346 in LDB3 show association with brain natriuretic peptide,DBP,and LVEF levels in patients with IDCM but did not show any association with IDCM susceptibility.