Relationship between circulating irisin levels and overweight/obesity: A meta-analysis
Relationship between circulating irisin levels and overweight/obesity: A meta-analysis作者机构：Affiliated Hospital of Jiangsu University Zhenjiang 212001 Jiangsu Province China Department of Library of Jiangsu University Zhenjiang 212001 Jiangsu Province China
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2019年第7卷第12期
页 面：1444-1455页
核心收录：
学科分类：10[医学]
基 金：Supported by the National Natural Science Foundation of China,No.81500351 the Youth Medical Talent Project of Jiangsu Province,No.QNRC2016842 the Jiangsu University Affiliated Hospital" 5123" Talent Plan,No.51232017305 the 169 Talent Project of Zhenjiang
主 题：Irisin Overweight/obesity Myokines Body mass index
摘 要：BACKGROUND Currently, the findings about irisin as a novel myokine related to obesity are inconsistent in overweight/obese people. To our knowledge, no systematic analysis has been conducted to evaluate the relationship between irisin levels and overweight/obesity. AIM To evaluate the association between circulating irisin levels and overweight/obesity. METHODS The Cochrane Library, MEDLINE, SCOPUS, and the ISI Web of Science were searched to retrieve all of the studies associated with circulating irisin levels and overweight/obesity. Standard mean difference values and 95% confidence intervals (CI) were estimated and pooled using meta-analysis methodology. RESULTS A total of 18 studies were included in our meta-analysis containing 1005 cases and 1242 controls. Our analysis showed that the circulating irisin level in overweight/obese people was higher than that in overall healthy controls (random effects MD = 0.63;95%CI: 0.22-1.05;P = 0.003). In the subgroup analysis by ethnicity, the irisin level was higher in overweight/obesity people than that in controls in Africa (random effects MD = 3.41;95%CI: 1.23-5.59;P 0.05) but not in European, Asian, or American populations. In addition, in a subgroup analysis by age, the results showed that obese children exhibited a higher irisin level than controls (random effects MD = 0.86;95%CI: 0.28-1.43;P 0.05). CONCLUSION This meta-analysis provides evidence that circulating irisin is higher in obese individuals compared to healthy controls and it is important to identify the relationship between circulating irisin levels and overweight/obesity in predicting overweight/obesity.
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