Cytokines and inflammation in adipogenesis:an updated review
作者机构：State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100730China
出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)
年 卷 期：2019年第13卷第3期
页 面：314-329页
核心收录：
基 金：the National Natural Science Foundation of China (Nos.81622008 and 81470579)(to Jing Wang).
主 题：cytokines inflammation adipogenesis type 2 diabetes mellitus metabolic disorder
摘 要：The biological relevance of cytokines is known for more than 20 years.Evidence suggests that adipogenesis is one of the biological events involved in the regulation of cytokines,and pro-inflammatory cytokines (e.g.,TNFα and IL-1β)inhibit adipogenesis through various pathways.This inhibitory effect can constrain the hyperplastic expandability of adipose tissues.Meanwhile,chronic low-grade inflammation is commonly observed in obese populations.In some individuals,the impaired ability of adipose tissues to recruit new adipocytes to adipose depots during overnutrition results in adipocyte hypertrophy,ectopic lipid accumulation,and insulin resistance.Intervention studies showed that pro-inflammatory cytokine antagonists improve metabolism in patients with metabolic syndrome.This review focuses on the cytokines currently known to regulate adipogenesis under physiological and pathophysiological circumstances.Recent studies on how inhibited adipogenesis leads to metabolic disorders were summarized.Although the interplay of cytokines and lipid metabolism is yet incompletely understood,cytokines represent a class of potential therapeutic targets in the treatment of metabolic disorders.
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