Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms

作     者：Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun 

作者机构：Department of Urology Beijing Hospital Beijing 100730 China Department of Urology Beijing Chao-Yang Hospital Beijing 100730 China Department of Urology The First Clinical College of Harbin Medical University Harbin Heilongiiang 150001 China Department of Urology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450003 China Department of Urology Peking University Shenzhen Hospital Shenzhen Guangdong 518036 China Department of Urology Nan Fang Hospital Guangzhou Guandong 440100 China Department of Urology The First Clinical College of Shanxi Medical University Taiyuan Shanxi 030012 China Department of Urology Southwest Hospital Chongqing 400038 China Department of Urology China Rehabilitation Center Beijing 100068 China Department of Urology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Urology Zhejiang Provincial People's Hospital Hangzhou Zhejiang 310014 China Department of Urology Changhai Hospital of Shanghai Shanghai 200433 China Department of Urology Ruijin Hospital Affiliated to The Shanghai Jiaotong University Medical School Shanghai 200025 China Department of Urology The First Hospital of China Medical University Shenyang Liaoning 110001 China Department of Urology The First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Urology Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Department of Urology Peking University People's Hospital Beijing 100044 China Department of Urology The General Hospital of the People's Liberation Army Beijing 100039 China Department of Urology Peking Union Medical College Hospital Beijing 100005 China Department of Urology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou Guangdong 510120 China Department of Urology The Second Xiangya Hospital of Central South University Changsha Hunan 410011 China Department of Urology Wuhan Union Hospital Wuhan Hubei 430022 China Department of Urology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116600 China Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science Wuhan Hubei 430030 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2014年第127卷第2期

页      面：261-265页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：TheAstellasPharmaChina Ltd 

主　　题：overactive bladder muscarinic antagonists symptom score 

摘      要：Background Overactive bladder （OAB） is a series of symptoms with high prevalence in elderly *** study was conducted using the overactive bladder symptom score （OABSS） to evaluate the efficacy of solifenacin succinate for the treatment of *** This was a prospective,multicenter,single-arm,12-week study that enrolled 241 OAB *** patients received 5-10 mg/day *** in OABSS,symptoms from voiding diary,perception of bladder condition （PPBC） score,international prostate symptom score （IPSS） and quality of life （QOL） were evaluated at weeks 0,4,and *** relationship between OABSS and PPBC score or parameters of voiding diary was also *** At baseline,the mean OABSS for all patients was 9.41±2.40,and was reduced significantly at week 12 （-3.76 points; 61.21％,P 0.0001）.The OABSS subscore,PPBC score,IPSS,and QOL were also significantly reduced during the study （P 0.0001）.The overall incidence of adverse events was 19.91％ （44 cases）.The gastrointestinal system was the most commonly affected （11.31％）.Around 5.88％ of the cases had adverse events related to the genitourinary *** was a strong correlation between OABSS and urinary symptoms that was recorded in the 3-day voiding *** We showed that solifenacin was clinically effective for relieving OAB symptoms,considering the balance between efficacy,patients＇ well-being,and *** integrates four OAB symptoms into a single score and can be a useful tool for research and clinical practice.