Fatalities caused by novel opioids:a review

作     者：Olaf H.Drummer Olaf H.Drummer

作者机构：Department of Forensic MedicineSchool of Public Health and Preventive MedicineFaculty of MedicineNursing and Health SciencesMonash UniversitySouthbankVictoriaAustralia 

出 版 物：《Forensic Sciences Research》 (法庭科学研究（英文）)

年 卷 期：2019年第4卷第2期

页      面：95-110页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Forensic science forensic toxicology opioids poisoning illicit drugs novel psychoactive drugs fentanyl derivatives mass spectrometry 

摘      要：Drugs related to morphine represent not only large range of important therapeutic applications for the relief of moderate to severe pain but also give rise to a relatively large series of novel opioids that mimic the action of this naturally occurring *** of these are based on fentanyl structures that are much more potent,and dangerous,than fentanyl *** publication reviews reports of fatalities attributed to 15 novel opioids with the view to assessing mortality associated with their misuse as well as reviewing published analytical procedures that would be able to detect these and other novel *** drugs include reports of deaths to acetylfentanyl,acrylfentanyl,butr(yl)fentanyl,carfentanil,2-and 4-fluorofentanyls,4-fluorobutyrfentanyl,4-fluoroisobutyrfentanyl,furanylfentanyl,a-and 3-methylfentanyls,4-methoxyfentanyl,ocfentanil,as well as AH-7921,U-47700 and *** of these cases reporting a drug-caused death involved other drugs in addition to the *** obvious minimum fatal concentration was discerned for any of the opioids for which details were provided,however,the more potent members required detection limits well under 1 ng/mL and often even well below 0.1 ng/mL requiring use of the most sensitive mass spectral detection procedures,particularly when screening specimens using a non-targeted *** other novel opioids have been reported in admissions to hospitals include 4-chloroisobutryfentanyl,cyclopentylfentanyl and tetrahydrofuranfentanyl,all of which are likely to have the potential to cause *** is also likely that other analogues will appear with time.