Ultrasonic findings of papillary thyroid carcinoma and its relationship with osteopontin expression
作者机构：Function Department of the Third People's Hospital of Hainan ProvinceSanyaHainan Province572000China Department of UltrasoundHainan Provincial People's HospitalHaikouHainan Province570311China Department of Laboratory of the Third People's Hospital of Hainan ProvinceSanyaHainan Province572000China
出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)
年 卷 期：2019年第25卷第7期
页 面：60-64页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Medical and Health Science and Technology Innovation Project of Sanya City. Project No: 2015YW33
主 题：Acoustic radiation force pulse imaging Cancerous goiter Osteopontin Ultrasonic appearance
摘 要：Objective: The ultrasonic findings of papillary thyroid carcinoma were analyzed by acoustic power pulse imaging, and the relationship between the expression of osteopontin and the expression of osteopontin was analyzed. Methods: Using color Doppler ultrasound in patients with lesions, morphology, internal echo, calcification and blood flow of the situation, and then switch to ARFI VTI mode and VTQ mode, VTI were measured with two-dimensional area and area ratio of VTQ mode SWV;osteopontin expression was detected in two groups of patients with thyroid tissues. Analysis of difference between the two the group index by using SPSS18.0 software, Pearson linear correlation method is used to analyze the area ratio and SWV value of thyroid tissue expression correlated with OPN. Results: The shape of papillary thyroid carcinoma nodules showed that the boundary was irregular and the shape of the nodules was burr. The shape of benign nodules was more than 1 with low echo in the interior. The shape of benign nodules showed clear boundary and middle hyperechoic in the interior. No calcification occurred in most lesions in that observation group, the area ratio in VTI mode is obviously higher than that of the control group, the difference was statistically significant (T=7.313, P=0.000), the SWV value in the VTQ model of the observation group was also significantly higher than that in the control group, the difference was statistically significant (t=43.334, P=0.000). The expression of OPNmRNA in the observation group was significantly higher than that of the control group , and the difference was statistically significant (t=8.894, P=0.000). Pearson linear correlation analysis showed that there was a significant positive correlation between OPNmRNA expression in papillary thyroid carcinoma and area ratio in VTI model and SWV course in VTQ model (r=0.235, 0.264;P0.05). Conclusion: It is important for the diagnosis of papillary thyroid carcinoma to use the technique of acoustic p
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