Knoevenagel condensation of α,β-unsaturated aromatic aldehydes with barbituric acid under non-catalytic and solvent-free conditions

作     者：Cherkupally Sanjeeva Reddy Adki Nagaraj 

作者机构：Department of ChemistryKakatiya UniversityWarangal 506009India 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2007年第18卷第12期

页      面：1431-1435页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

主　　题：Barbituric acid Knoevenagel condensation 5-(Arylpropenylidine)-2,4,6-pyrimidinetrione 

摘      要：An efficient route for the synthesis of 5-（arylpropenylidine）-2,4,6-pyrimidinetrione 3 from an appropriate α,βunsaturated aromatic aldehydes 1 and barbituric acid 2 under both non-catalytic and solvent-free microwave irradiation conditions was described. In this way, a range of biologically important compounds 3 was obtained in good to excellent yields （86-98%） in a very short reaction time （30-80 s）.