A microbially based approach for the asymmetric synthesis of both enantiomers of R-and S-fluoxetine
A microbially based approach for the asymmetric synthesis of both enantiomers of R-and S-fluoxetine作者机构：Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：1992年第10卷第4期
页 面：355-358页
核心收录：
主 题：A microbially based approach for the asymmetric synthesis of both enantiomers of R and S fluoxetine
摘 要：Both enantiomers of fluoxetine were synthesized in five steps from ethyl benzoylacetate (1)using microbial-chemical approach with overall yields of 59% and 62% respectively.(S)-Enan- tiomer can be obtained in 99% *** resting cell of baker s yeast and the R form was produced in 81 % *** immobilized Geotrichum sp.G 38.
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