An efficient synthesis of isocoumarins via a CuI catalyzed cascade reaction process

作     者：WANG LeiLei ZHANG XiaoJing JIANG YongWen MA DaWei 

作者机构：Shenyang Pharmaceutical UniversityShenyang 110016China State Key Laboratory of Bioorganic Chemistry and Natural ProductsShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2009年第52卷第10期

页      面：1616-1621页

核心收录：

学科分类：081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 

基　　金：Supported by the National Natural Science Foundation of China (Grant Nos. 20621062 & 20872156) 

主　　题：coupling cascade reaction copper iodide isocoumarins 

摘      要：3-Alkyl isocoumarins are provided by CuI/amino acid-catalyzed Sonogashira coupling reaction of o-bromo benzoic acids and terminal alkynes and the subsequent additive cyclization. This cascade process allows synthesis of diverse isocoumarins by varying both coupling partners bearing a wide range of functional groups.