Correlation of continuous electroencephalogram with clinical assessment scores in acute stroke patients

作     者：Xiyan Xin Ying Gao Hua Zhang Kegang Cao Yongmei Shi 

作者机构：Department of Neurology Dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100700 China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2012年第28卷第5期

页      面：611-617页

核心收录：

学科分类：090603[农学-临床兽医学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 09[农学] 0906[农学-兽医学] 10[医学] 

基　　金：supported by grants from the Beijing Municipal Science and Technology Commission, China (D08050703020805) the National Major Science and Technology Special Project of China(2009JYBZZ-XS060) the Innovation Team Project of Beijing University of Chinese Medicine, China (2011-CXTD-22) 

主　　题：electroencephalography brain symmetry index stroke prognosis 

摘      要：Objective To compare electroencephalogram （EEG） symmetry values between stroke patients with different 28-day outcomes, and to assess correlations between clinical characteristics and 28-day outcomes. Methods Twenty-two patients presenting with acute ischemic stroke and persistent neurological deficits at EEG recording were incrementally included. At 28 days after admission, the modified Rankin scale （mRS） was used to evaluate the outcomes, based on which the patients were divided into two a posteriori groups, mRS = 6 and mRS 〈6. Student＇s t-test was used to compare these two groups in terms of brain symmetry index （BSI）, National Institutes of Health stroke scale （NIHSS）, Glasgow coma scale （GCS） and acute physiology and chronic health evaluation II （APACHE II） assessed at admission. Then EEG parameters, NIHSS, GCS and APACHE II were correlated with the mRS. Results There were significant differences in BSI, NIHSS, GCS, and APACHE II between the two groups. Survivors had lower BSI, NIHSS and APACHE II, and higher GCS values, compared with patients who died within 28 days after admission. Besides, BSI at admission had a positive correlation with mRS at 28 days （r = 0.441, P = 0.040）. NIHSS and APACHE II were also correlated with mRS （r = 0.736, P 〈0.000 1; r = 0.667, P = 0.001, respectively）. GCS at admission had a negative correlation with mRS （r = 0.656, P = 0.001）. Conclusion A higher BSI predicts a poorer short-term prognosis for stroke patients. Acute EEG monitoring may be of prognostic value for 28-day outcomes. The early prediction of functional outcomes after stroke may enhance clinical management and minimize short-term mortality.