Hyaluronic acid inhibited the upregulation of heat-shock protein 70 in human chondrocytes from osteoarthritis and Kashin-Beck disease

作     者：ZONGQIANG GAO XIONG GUO JUNCHANG CHEN CHEN DUAN 

作者机构：Department of OrthopedicsThe Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi710004China Institute of Endemic DiseasesFaculty of Public HealthCollege of MedicineXi’an Jiaotong UniversityKey Laboratory of Environment and Genes Related to DiseasesMinistry of EducationXi’anShaanxi710061China 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2019年第43卷第2期

页      面：99-102页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Supported by Project of Science and Technology of Social Development in Shaanxi Province(No.2013SF2-10) Shaanxi Science&Technology Coordination&Innovation Project(No.2015KTCQ03-01) 

主　　题：Hyaluronic acid Kashin-Beck disease Osteoarthritis Chondrocyte HSP70 

摘      要：This study aimed to investigate the effect of hyaluronic acid(HA)on the expression of heat-shock protein 70(HSP70)in chondrocytes isolated from patients with osteoarthritis(OA)and Kashin-Beck disease(KBD).The chondrocytes were collected from OA and KBD patients,and chondrocytes isolated from patients of accident injuries were used as the *** chondrocytes were treated with HA at different ***70 expression in chondrocytes at both mRNA and protein levels was tested by PCR and Western blot *** with control,both mRNA and protein levels of HSP70 were higher in chondrocytes from KBD and ***,HA at the dose of 500μg/mL significantly inhibited HSP70 expression levels in both KBD and OA groups(P0.05).In conclusion,HSP70 is highly expressed in chondrocytes of patients of OA and *** intervention inhibits the upregulation of HSP70 in chondrocytes of OA and KBD patients and could be a promising agent for treatment of OA and KBD.