Syntheses of DL-threo-Thiamphenicol via Green Oxidation

作     者：LIU Kai Robert Franzén YU Xiao-jing ZHANG Jun XU You-jun 

作者机构：School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China Institute of Materials Chemistry Tampere University of Technology Korkeakoulunkatu 8 FIN-33720 Tampere Finland 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2006年第22卷第5期

页      面：602-605页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 10[医学] 

主　　题：Green oxidation Hydrogen peroxide Sodium tungstate Thiamphenicol 

摘      要：Four methyl aryl thioethers related to thiamphenicol syntheses and methyl phenyl sulfide were cleanly oxidized into methyl sulfones in high to excellent yields via catalytic green oxidation with aqueous hydrogen peroxide in combination with sodium tungstate. When the same reactions were similarly performed in the absence of the catalyst, the corresponding sulfoxides could be obtained. This viable synthetic approach for the synthesis of DL-threo-thiamphenicol is a simple procedure, which has an economic advantage in view of its application for the large-scale synthesis because it can be carried out under mild conditions.