Synthesis and cytotoxic activity of 3-phenyl-4-substituted-β-carbolines

作     者：Liu Liu Ying Ying Xu Ze Qi Yang Jian Nan Xiang Guang Yu Xu 

作者机构：Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education)College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2012年第23卷第11期

页      面：1230-1232页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 10[医学] 

基　　金：supported by NSFC(No.20602010) Scientific Research Fund of Hunan Provincial Education Department(No.10B061) and Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province 

主　　题：β-Carboline Synthesis Iodine-mediated cyclization Cytotoxicity Harmine 

摘      要：A new class of 3-phenyl-4-substituted-β-carbolines via iodine-mediated electrophilic cyclization as key step were synthesized and their inhibitory activity against three tumor cell lines was evaluated in vitro. It was found that some of the tested compounds showed better cytotoxicity against HeLa and MCF-7 cells than harmine.