Effect of volatile oil from Blumea Balsamifera(L.) DC. leaves on wound healing in mice
Effect of volatile oil from Blumea Balsamifera(L.) DC. leaves on wound healing in mice作者机构:Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural Sciences Medicinal Efficacy Evaluation Laboratory Hainan Provincial Engineering Research Center for Ainaxiang (Herba Blumeae Balsamiferae) Key Laboratory of Tropical Crop Gene Resources and Germplasm Enhancement of Ministry of Agriculture College of Traditional Chinese Medicine Guangdong Pharmaceutical University College of Traditional Chinese MedicineGuangdong Pharmaceutical University
出 版 物:《Journal of Traditional Chinese Medicine》 (中医杂志(英文版))
年 卷 期:2014年第34卷第6期
页 面:716-724页
核心收录:
学科分类:1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金:the Fundamental Scientific Research Funds for Chinese Academy of Tropical Agricultural Sciences-Tropical Crops Genetic Resources Institute[The Evaluation and Mechanism Research for the Treatment of Ainaxiang(Herba Blumeae Balsamiferae)Oil on Skin Burns Based on Cytokines,No.#1630032014016] the Natural Science Fund of Hainan Province[the Evaluation and Mechanism Research of Ainaxiang(Herba Blumeae Balsamiferae)Oil on Healingand Repairing of Skin Wounds,No.#312022] the Natural Science Fund of China(Study on Variety Classification of"Nalong"and It's Ethanopharmacology of Li in Hainan,No.#81374065)
主 题:WoundBlumea Balsamifera (L.)cumhealing Neuropeptides DC. Borneolum Synthciticum
摘 要:OBJECTIVE: To assess the effectiveness of violateoil from Blumea Balsamifera(L.) DC. leaves(BB oil)on wound healing in ***: Undiluted BB oil and its diluted solutions with olive oil to 1/5 and 1/10 to yield BB oil1/5and BB oil1/10 were applied to the wounded skin before wound healing conditions were assessed by healing rate, histopathology, and contents of collagen, hydroxyproline, and Neuropeptide Substance P(SP). All above results were compared with the efficacies of the control, pure olive oil, basic fibroblast growth factor(BFGF), and cream of Jing Wan Hong(JWH).RESULTS: BB oil1/5and BB oil1/10 improved wound contraction and closure. Histopathology study further confirmed a desirable histological organization of wound tissues. BB oil1/5and BB oil1/10 reduced the number of inflammatory cells, increased wound-healing rates, and significantly increased the hydroxyproline content. Both BB oil1/5and BB oil1/10 improved formation of collagen, and reduced the frequency of fibroblasts. Moreover, BB oil1/5and BB oil1/10 markedly promoted SP expression. However, undiluted BB oil may induce skin thickening and hardening, inhibite collagen synthesis and delay complete skin wound ***: The BB oil1/5and BB oil1/10 promoted capillary regeneration, blood circulation, collagen deposition, granular tissue formation, epithelial deposition, and wound contraction. The mechanism underlying the action might be related to induction of SP secretion, and the proliferation and differentiation of mesenchymal cells.