Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis

作     者：CHANG Jun-li WANG Wen-yi LI Yi-mian HU Shao-pu YAO Min CUI Xue-jun ZHI Wen-lan SHI Qi WANG Yong-jun YANG Yan-ping 

作者机构：Orthopedic SurgeryLonghua HospitalShanghai University of Traditional Chinese MedicineShanghai(200032)China Institute of SpineShanghai University of Traditional Chinese MedicineShanghai(200032)China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2019年第25卷第5期

页      面：370-377页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Supported by the National Nature Science Foundation of China(Nos.81674006,81603343,and 81330085) the Program for Innovative Research Team of Ministry of Science and Technology of China(No.2015RA4002) 

主　　题：Chinese herbal medicine osteosarcoma systematic review meta-analysis mouse xenograft model 

摘      要：Objective: To summarize and critically assess the inhibitory effects of Chinese herbal medicine(CHM) on tumor volume and tumor weight for the treatment of osteosarcoma(OS) in mouse models. Methods:PubMed, Embase, Web of Science, China Knowledge Resource Integrated Database(CNKI), Wanfang Database, VIP Database, and Chinese BioMedical(CBM) were searched since their inception dates to March10, 2016. Two reviewers independently selected the controlled studies estimating effects of CHM on mouse OS by administration in vivo. A pair-wise meta-analysis was performed. Twenty-five studies with adequate randomization were included in the systematic review. Results: CHM may signi?cantly inhibit OS growth in mice, as assessed using the tumor weight [20 studies, n=443; 290 for CHM and 153 for the control; pooled mean difference(MD)=–2.90; 95% confidence interval(CI): –3.50 to –2.31; P0.01], tumor volume(16 studies, n=382; 257 for CHM and 125 for the control; pooled MD =–2.57; 95% CI: –3.33 to –1.80; P0.01) and tumor growth inhibition rate. Conclusion: CHM could significantly inhibit the growth of OS in mouse models,which might be supportive for the design of preclinical and clinical trials in future.