Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization

作     者：Koen Vercauteren Ahmed Atef Mesalam Geert Leroux-Roels Philip Meuleman 

作者机构：Center for VaccinologyGhent University Hospital Ghent University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第43期

页      面：15975-15991页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by Ghent University,Grants No.01G00507 and No.01G01712 Research Foundation-Flanders,Projects No.1500910N,No.G0212.10N and No.G052112N(FWO-Vlaanderen) Belgian Federal Government,No.IUAP P6/36-HEPRO and No.P7/47-HEPRO-2 European Union No.FP6 HEPACIVAC FP7,Hepa Mab Mesalam AA is a recipient of a PhD Fellowship provided by the Egyptian government 

主　　题：Hepatitis Lipids Neutralisation Antiviral therapy Animal models 

摘      要：Hepatitis C virus(HCV)infections represent a major global health ***-stage liver disease caused by chronic HCV infection is a major indication for liver ***,after transplantation the engrafted liver inevitably becomes infected by the circulating *** acting antivirals are not yet approved for use in liver transplant patients,and limited efficacy and severe side effects hamper the use of pegylated interferon combined with ribavirin in a post-transplant ***,alternative therapeutic options need to be *** entry represents an attractive target for such therapeutic *** the mechanisms of viral entry is essential to define the viral and cellular factors *** HCV life cycle is dependent of and associated with lipoprotein physiology and the presence of lipoproteins has been correlated with altered antiviral efficacy of entry *** thisreview,we summarise the current knowledge on how lipoprotein physiology influences the HCV life *** focus especially on the influence of lipoproteins on antibodies that target HCV envelope proteins or antibodies that target the cellular receptors of the *** information can be particularly relevant for the prevention of HCV re-infection after liver transplantation.