Fluorescence triggered by ligand-protein hydrophobic interaction

作     者：LIU ZhenZhen DU LuPei LI MinYong 

作者机构：Department of Medicinal ChemistrySchool of PharmacyShandong University 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2013年第56卷第11期

页      面：1667-1670页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China (81370085) the Program of New Century Excellent Talents in University (NCET-11-0306) the Fok Ying Tong Education Foundation (122036) the Shandong Natural Science Foundation (JQ201019) the Independent Innovation Foundation of Shandong University (2010JQ005 and 2012JC002) 

主　　题：non-enzyme protein environment-sensitive probe turn-on fluorescence SBD fluorophore 

摘      要：Hydrophobic fluorescence:Tan and his colleagues recently introduced a brand new chemotype of environment-sensitive fluorescent turn-on probes to detect the hydrophobic ligand-binding domain by using SBD *** design strategy described in this report generalized the environment sensitivity turn-on mechanism to recognize a specific protein,which provides a robust breakthrough for interchanging fluorescence in conventional small-molecule fluorescent imaging.