S100A4 in esophageal cancer:Is this the one to blame?

作     者：Jianyuan Chai M Mazen Jamal 

作者机构：Laboratory of GI Injury and Cancer VA Long Beach Healthcare System Long Beach CA 90822 United States Division of Gastroenterology Department of Medicine University of California Irvine CA 92868 United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第30期

页      面：3931-3935页

核心收录：

学科分类：0710[理学-生物学] 090603[农学-临床兽医学] 1002[医学-临床医学] 07[理学] 09[农学] 0906[农学-兽医学] 

基　　金：Supported by The Department of Veterans Affairs of the United States 

主　　题：Esophageal cancer S100A4 Metastasis 

摘      要：Metastasis is the main reason for cancer-related death.S100A4 is one of the key molecules involved in this *** studies have shown that overexpression of S100A4 in non-metastatic cancer cells can make them become metastatic,and knockdown of S100A4 in metastatic cancer cells can curtail their invasive nature.A study by Chen et al published in the World J Gastroenterol 18(9):915-922,2012 is a typical *** study showed in vitro and in vivo evidence that S100A4 expression level determines the invasiveness of esophageal squamous *** the fact that more than half of the cancer-related deaths are caused by malignancies derived from the digestive system and esophageal cancer is the 4th top contributor to this fraction,this study warrants more attention.