Role of colonoscopy in diagnosis of capecitabine associated ileitis:Two case reports

作     者：Alexander E Dao Angela Hsu Ahmad Nakshabandi Rohan Mandaliya Sandeep Nadella Anita Sivaraman Mark Mattar Aline Charabaty 

作者机构：Department of GastroenterologyMedstar Georgetown University Hospital Department of GastroenterologyJohns Hopkins University at Sibley Memorial Hospital 

出 版 物：《World Journal of Gastrointestinal Endoscopy》 (世界胃肠内镜杂志（英文版）（电子版）)

年 卷 期：2019年第11卷第5期

页      面：383-388页

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Capecitabine Xeloda 5-Fluorouracil Ileitis Ileocolitis Colonoscopy Case report 

摘      要：BACKGROUND Capecitabine is considered a first line agent in adjuvant therapy for breast and colorectal cancer. However,cases of severe diarrhea have been reported with increasing frequency in recent years. When diarrhea is severe and prolonged,capecitabine associated ileitis should be considered as a possible *** SUMMARY Herein,we present two cases of capecitabine ileitis,specifically involving the terminal ileum and ascending colon. We will demonstrate the disease course and treatment modalities applied to alleviate this condition,as well as discuss the merits of using colonoscopy to aid in *** Ultimately our cases demonstrate that symptomatic management with traditional anti-diarrheal medications is largely ineffective. Prompt recognition and discontinuation of capecitabine is an imperative step in proper management of this condition and colonoscopy with biopsy can be helpful when the diagnosis is unclear.