Effect of Cognitive Behavioral Intervention Therapy on Immune Index in Patients with Breast Cancer
Effect of Cognitive Behavioral Intervention Therapy on Immune Index in Patients with Breast Cancer作者机构：University of South China Hengyang China Xiangya School of Medical Affiliated Haikou Hospital Haikou China Central South University Changsha China Department of Psychology Hainan General Hospital Haikou China Lin Gao County People’s Hospital of Hainan Province Hainan China
出 版 物：《Advances in Breast Cancer Research》 (乳腺癌（英文）)
年 卷 期：2019年第8卷第2期
页 面：77-85页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Cognitive Behavioral Therapy Breast Cancer Stress Response Coping Style
摘 要：Objective: To explore the effect of cognitive behavioral intervention therapy on the cellular immune function of patients undergoing radical mastectomy for the first time, and to provide a scientific basis for improving the treatment of breast cancer patients. Methods: 100 patients with breast cancer who were eligible for admission to the Department of Breast Surgery, Hainan Provincial People’s Hospital from January 2016 to December 2017 were selected as subjects. It is the first time to improve the radical mastectomy. They were randomly divided into control group and intervention group, 50 cases each. The control group used conventional treatment and routine care. On the basis of this, the intervention group conducted cognitive behavioral interventions including cognitive reconstruction and behavioral therapy. The patients were measured for serum IL-2, IL-4, IL-6, IL-8 and TNF-α levels on the second day after admission and three months after discharge. The changes of serum IL-2, IL-4, IL-6, IL-8 and TNF-α levels in the two groups were compared before and after cognitive intervention. Results: The concentrations of IL-2, IL-4, IL-6, IL-8 and TNF-α in the serum of the intervention group and the control group before intervention were compared. The difference was not statistically significant (P 0.05). After the intervention, the serum levels of IL-2, IL-4 and IL-8 in the intervention group were lower than before the intervention. The concentration of TNF-α was higher than before the intervention. The difference was statistically significant (P Conclusion: Cognitive behavioral intervention therapy can change the levels of IL-2, IL-4, IL-6, IL-8 and TNF-α in serum of breast cancer patients. It has a positive effect on the regulation of immune function in breast cancer patients.
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